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Elucidating the Role of the Extracellular Matrix as an Event Trigger in Muscle Tissue Recycling


梅津 大輝 (大阪大学 大学院理学研究科, 講師) 

Daiki Umezu (Osaka Univ.)

研究紹紹介図 - Daiki Umetsu.png


In various tissues of our body, old cells are removed and replaced by newly born cells. The extracellular matrix (ECM), essential for the survival of many types of the cell, is believed to play an important role in this cell replacement process. The phenomenon of cell replacement in various tissues observed during metamorphosis of amphibians and insects is an extreme example of such tissue remodeling. In this process, most of the cells that originally formed the tissue or organ are lost simultaneously due to cell death, and another cell population proliferates to reconstruct the tissue. However, the relationship between cell removal and the ECM in tissue remodeling is largely unexplored. Our research group has obtained data suggesting that muscle fragments derived from old muscle tissue are recycled into new muscle tissue during tissue remodeling observed in the Drosophila metamorphosis. It is possible that the ECM functions as an event trigger initiating this series of muscle tissue remodeling processes. Therefore, this project aims to elucidate the cell-to-cell interactions induced by ECM degradation and clarify part of the multimodal roles of the ECM.

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