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Achievements

multimodal.ecm[at]gmail.com (Please replace [at] with @)

151) Basement membrane components define the microenvironment of aggregated fibroblasts in the skin and support their aggregation in vitro

Machida H, Yokota J, Fujiwara H

Matrix Biol.

150) Multimodal analysis of surface states underlying hydrogel adhesion

Akimoto AM, Tanaka N, Nihonyanagi S, Ohta Y, Enomoto T, Kuwabara N, Gao Y, Koizumi Y, Honjo K, Tahara T, Yoshida R

Res. Sq.

149) Posterior Shift of Shh–Fgf Signaling in Axolotl Limb Regeneration Drives Sequential Digit Formation

Furukawa S, Yamamoto S, Nakayama H, Ohashi A, Satoh A

iScience

 

148) Tendon regeneration ability in axolotl limbs

Amada R, Yamamoto S, Ohashi A, Nakayama H, Furukawa S, Satoh A

Zool. Sci.

147) Shear stress induces concentration gradient distributions of membrane proteins in live cells

Yamashiro S, Nomura N, Chapin N, Sasidharan S, Elverston L, Nagao K, Knepper L, Thévenin D, Watanabe N, Honerkamp-Smith AR

Biophys. J., in press

146) Lysophosphatidic acid mitigates vascular permeability and allergic rhinitis in mice

Shimizu A, Hayashi Y, Hosoe N, Takara K, Lynda L, Ishida R, Kato Y, Fujieda S, Kidoya H

Allergol Int., S1323-8930(26)00041-9 (2026)

145) Tolerance to extracellular acidic pH facilitates tumor plasticity

Hasegawa M, Xu B, Maeda K, Seki M, Cai F, Cui R, Ando R, Nakagawa S, Sakamoto A, Boycott C, Yatabe H, Nishida M, Matsumoto K, Iwabuchi-Yoshida C, Aki S, Yamagata K, Tsuchida R, Takahashi M, Kuribayashi F, Kidoya H, Hirata H, Matsumoto S, Sando S, Yanai H, Yachie N, Osawa T

Cell Rep., 117226 (2026)

144) Injectable Thixotropic Hydrogel Composed of Elastin-Like Polypeptide and Oxidized Dextran for Anastomotic Support

Aoyama Y, Nakano Y, Shinozuka T, Aoki K, Suzuki K, Ohtsuki C, Kanda M, Sugawara-Narutaki A

NPG Asia Mater., in press

143) Energetics-based model for a diffusiophoretic motion of a deformable droplet

Kitahata H, Koyano Y, Kobayashi Y, Nagayama M

Phys. Rev. E, 113:035408 (2026)

142) Quantifying Lysosomal Degradation of Extracellular Proteins With a Fluorescent Protein-Based Internalization Assay

Bun S, Kamikawa K, Matsuura A, Itakura E

Bio Protoc, 16(5):e5619.(2026)

141) The integration mechanism of the four positional cues—anterior, posterior, dorsal, and ventral—in axolotl limb regeneration

Yamamoto S,  Furukawa S, Ohashi A, Hamada M, Satoh A

eLife, (2025)

140) Down-regulation of proliferation-inhibiting factor EGR1 in brain metastatic cancer cells on a soft matrix

Omukai M, Ishihara S, Hirata E, Haga H

Cell Struct. Funct., 51(1):139-146(2026)

139) Click-crosslinked nanogels integrated into 3D stem cell spheroids enhance regenerative function for swallowing muscle repair

Okuyama H, Brown M, Munipalle M, Nejati S, Huo R, Sakata H, Mizuta R, Sasaki Y, Akiyoshi K, Ohnishi H, Kishimoto Y, Omori K, Li Ji, Mongeau L, Li-Jessen NYK

Biomaterials, 330 (2026)

138)  Antitumor Effects of PD-1 Blockade Combined with Mild Hyperthermia in a Murine Osteosarcoma Model

Izubuchi Y, Hosoe N, Tanaka T, Watanabe Y, Kobayashi T, Nakajima H, Kidoya H, Matsumine A

 Biomedicines, 14(2):341 (2026)

137) Planar cell polarity emerges through polarized accumulation of Wnt11

Mii Y, Suzuki M, Koyama H, Nakayama K, Takada R, Kobayashi T, Tsutsumi M, Nemoto T, Matsuyama M, Fujimori T, Takada S

Sci. Adv., 12, eaea0326 (2026)

136) FGF2 Rescues Denervation-Induced Muscle Atrophy in Ambystoma mexicanum

Nakayama H, Ohashi A, Yamamoto S, Furukawa S, Satoh A

Skeletal Muscle, in press

135) Glomerular basement membrane structural integrity dictates trans-tissue deposition of laminin in the kidney 

Omachi K, Lin MH, Puapatanakul P, Begin JF, McKee KK, Fujiwara H, Yurchenco PD, Miner JH

Cell Rep., 45(3):117006 (2026)

134) Fibroblast-specific palladin drives kidney fibrosis via MRTF-SRF signaling

Yamamoto N, Sakai N, Yamamura Y, Kaikoi D, Hayashi D, Matsuno T, Koshino A, Sako K, Horikoshi K, Yuasa T, Tamai A, Minami T, Oshima M, Nakagawa S, Kitajima S, Hara A, Shimizu M, Terakawa J, Horike SI, Daikoku T, Mizokami A, Ikeda H, Kadoguchi M, Arakawa H, Ohtsuki S, Lagares D, Wada T,  Iwata Y

J. Pathol., 268(1):40-53 (2026)

133) Zinc-MTF1-metallothionein axis plays critical roles in the defense against ferroptosis in human cells

Wagatsuma T, Yamamoto A, Nishimura Y, Kawami M, Ito J, Hirayama T, Masuda S, Nakagawa K, Uchida Y, Kambe T

Free Radic. Biol. Med., 245:390-404 (2026)

132) scSurv: a deep generative model for single-cell survival analysis

Mizukoshi C, Kojima Y, Hayashi S, Abe K, Kasugai D, Shimamura T

Bioinformatics, 42(1):btaf671 (2026)

131) Reprogramming of Alveolar Macrophages by the Bacterial Peptide iEDAP via PEPT2 Transport

Kawami M, Takeuchi Y, Fuji K, Yumoto R, Takano M, Uchida Y

Toxicol. Res., (2025)

130) Peristaltic contractions drive gut anisotropic growth through collective cell rearrangements

Kawamura K, Takahashi Y, Inaba M

bioRxiv, (2025)

129) Non-migratory mode of ventral body wall closure: Primary mid-ventral covering is replaced by prospective definitive body wall

Buma K, Takahashi Y

Dev. Dyn., (2025)

128) Endothelial IRE1 signaling maintains blood-brain barrier integrity and limits neuroinflammation after traumatic brain injury 

Fan Q, Takarada-Iemata M, Tanaka T, Nguyen LD, Okitani N, Yang R, Tamatani T, Ishii H, Hattori T, Kidoya H, Kubota Y, Iwawaki T, Hori O

Cell Death Dis, 17(1):210 (2026)

127) P-LM421E8, the heparan sulfate chain-conjugated laminin-421-E8 fragment, drives differentiation of human induced pluripotent stem cells into hematopoietic progenitor cells comparable to basic fibroblast growth factor in a chemically defined system

Ninomiya N, Sasaki K, Katori R, Shimizu Y, Fujita K, Taniguchi Y, Kunieda T, Tamura K, Yamada M, Sekiguchi K, Kimura H

Matrix Biol. Plus, 29 (2026) 100188

126) Designing Cross-Linked Nanogel Microfibers for the Fabrication of Hybrid Cell Spheroids with Potential Biomedical Applications

Sakata H, Hayashi S, Kinoshita N, Harada H, Mizuta R, Sawada SI, Akiyoshi K, Sasaki Y

ACS Biomater. Sci. Eng., 12(1): 489-497 (2025)

125) Anti-aligning Self-propelled Model of Two Species: Emergence of Self-organized Heterogeneous Aligned and Clustered Order

Oki T, Hatakeyama TS, Nishikawa S, Ishihara S, Namba T

J. Phys. Soc. Jpn., 95, 013001 (2026)

124) SRRM4 Knockout Helps the Human Mesenchymal Stem Cell Line to Penetrate Decellularized Cancellous Bone

Onishi I, Muraoka K, Koyanagi A, Kimura T, Kishida A, Kitagawa M, Kurata M

Bioengineering, 12: 1299 (2025)

123) CRPPA exon 6-9 deletion as a founder mutation in Chinese patients with dystroglycanopathy

Luo J, Liu Y, Song D, Yang S, Fu X, Ge L, Wei C, Cui L, Fan Y, Luo H, He Y, Xu J, Shen Q, Guo Y, Kanagawa M, Toda T, Wang J, Zhang H, Xiong H

Pediatr. Investig., 10(1):25-37 (2025)

122) Laminin-511-functionalized fibrin gel enables in-gel proliferation of human induced pluripotent stem cells

Taniguchi Y, Takizawa M, Hada A, Ishimaru A, Sekiguchi K

Matrix Biol., 142:21-32 (2025)

121) Mapping intracellular dynamics across the whole cell with spatial statistics

Okabe Y, Saito T, Nakashima O, Matsunaga D, Deguchi S

 Biophys. J., 124(23):42054214 (2025)

120) Decellularized porcine pericardium supports periodontal ligament tissue regeneration and attenuates root resorption in a tooth replantation model

Hsiao M, Kimura T, Suzuki M, Hashimoto Y, Yamada M, Kim Y, Harazono Y, Yoshitake H, Terauchi M, Kishida A, Yoda T

Dent Mater J, 45(1): 72-82 (2026)

119) Ataxin-2 as a candidate blood biomarker for estimating disease status in cases of suspected glioblastoma recurrence

Garaeva F, Nakajima R, Tamai S, Tateishi K, Mukasa A, Kawabata S, Nagashima H, Natsumeda M, Hirai N, Tanaka S, Ohba S, Higa N, Arakawa Y, Kondo A, Kohzuki H, Koizumi S, Fujioka Y, Abe T, Sabit H, Kinoshita M, Uchida Y, Ohtsuki S, Nakada M

Brain Tumor Pathol., 43:43-55 (2026)

118) RNA velocity and beyond: Current advances in modeling single-cell transcriptional dynamics

Shimamura T

Allergol Int., 74(4):525-533 (2025)

117) Protocol to culture cells on genipin-mixed collagen gels with different stiffnesses

Ishihara S, Haga H

STAR Protoc, 6(4):104125.(2025)

116) Adaptive flexibility of cells through nonequilibrium entropy production

Ueda Y, Deguchi S

BioSystems, 257:105594 (2025)

115) Shear-induced irreversible gelation of silica nanoparticle dispersions containing amphiphilic block copolymer

Niwa S, Katayama S, Nakamura J, Ohtsuki C, Sugawara-Narutaki A

MRS Commun., 15:1137-1143 (2025)

114) Exploring basement membrane dynamics through cross-scale imaging, manipulation, and molecular mapping

Omachi K, Fujiwara H

Matrix Biol., 141:67-81 (2025)

113) A novel method to fabricate elastin/collagen fiber composites: Proof of concept

Shinokawa K, Sugawara-Narutaki A, Kim J, Matsumoto T, Maeda E

MATER LETT-X, 26: 100255 (2025)

112) Nephronectin Mediates the Interaction between Hair Follicle Epithelial Progenitors and Dermal Stem Cells and Is Involved in Hair Cycle Progression

Liu W, Sanzen N, Abe T, Kiyonari H, Barker N, Hu Z, Fujiwara H

J Invest Dermatol, 146(3):815-819 (2026)

111) ECM-Preserving Decellularization of Dermis via Subtle Cell Membrane Disruption Induced by Subcritical Dimethyl Ether

Nakamura N, Tanabe K, Fukuhara H, Otsuki K, Shimotomai M, Shiba S, Kimura T, Kishida A

ACS Omega, 10(34): 39002-39011 (2025)

110) Differential spreading behaviors of Nodal signalling molecules in the extracellular space cooperatively shape left-right asymmetry

Ikeda T, Kawanishi T, Mii Y, Yabe T, Pelliccia J, Burdine RD, Takeda H

bioRxiv, (2025)

109) Structural characterization of newt tendon regeneration after complete transection: In vivo two-photon imaging and transmission electron microscopy

Kamiya T, Ito Y, Iwasaki T, Suzuki D, Hayashi T, Kim J, Matsumoto T, Maeda E

J. Anat., 248(3):383-394 (2025)

108) Comparative Proteomic Analysis of Endocytic Cell-Surface Proteins in Vascular and Lymphatic Endothelial Cells

Ito S, Ohishi M, Yamahiro M, Masuda T, Ohtsuki S

Biol. Pharm. Bull., 48(8):12224-1232 (2025)

107) Single-cell transcriptomic reconstruction of the human hair cycle: Capturing the temporal dynamics of skin tissue remodeling

Yokota J, Gomi T, Harada Y, Yo K, Ahn K, Sanzen N, Machida H, Shirai Y, Fujiwara H

Cell Rep., 23;44(9):116196 (2025)

106) Biological role and clinicopathological significance of leucine-rich α-2 glycoprotein 1 in the glioblastoma microenvironment

Furuta T, Miyoshi H, Moritsubo M, Nakajima R, Negoto T, Nakamura H, Morioka M, Uchida Y, Ohtsuki S, Nakada M

J Neuropathol Exp Neurol, 84(8):707-714 (2025)

105) Evaluation of the False Discovery Rate in Library-Free Search by DIA-NN Using In Vitro Human Proteome

Gu K, Kenko M, Ogawa K, Goshima N, Masuda T, Ito S, Ohtsuki S

J. Proteome Res., 24(8):3874-3883 (2025)

104) Effects of SLC6A8 mutation-induced creatine deficiency on cellular function in fibroblasts

Ito S, Uemura T, Miyano A, Shimbo H, Masuda T, Goto T, Osaka H, Wada T, Ohtsuki S

Sci. Rep., 15(1):26738 (2025)

103) Functional assessment of immortalized human brain microvascular endothelial cells with different passage numbers: A case study for a prospective proposal on variability management of in vitro blood-brain barrier models

Ohki S, Fukuda M, Baba T, Wakayama N, Morio H, Ito S, Ohtsuki S, Yamaura Y, Komori T, Furihata T

DMPK, 62, 101058 (2025)

102) Active matter under cyclic stretch: Modeling microtubule alignment and bundling

Tagaki T, Nishikawa S, Ishihara S

Phys. Rev. E, 112:034405 (2025)

101) Wnt-dependent mechanism of the apical constriction of roof plate cells in developing mouse spinal cord

Shinozuka T, Okubo T, Sasai N, Takada S

Front. Cell Dev. Biol., 13:1571770 (2025)

▶︎ 1) ~ 100) 

hironobu.fujiwara[at]riken.jp (Please replace [at] with @)

​Transformative Research Area (A)   Multimodal ECM

Copyright ©  Multimodal ECM  All Rights Researved

学術変革A マルチモダルECM​

Leader: Hironobu Fujiwara

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