文部科学省 科学研究費補助金 学術変革領域研究 (A) 2023〜2027年度
FY2023-2027 MEXT KAKENHI Grant-in-Aid for Transformative Research Area (A)
Achievements
multimodal.ecm[at]gmail.com (Please replace [at] with @)
151) Basement membrane components define the microenvironment of aggregated fibroblasts in the skin and support their aggregation in vitro
Machida H, Yokota J, Fujiwara H
Matrix Biol.
150) Multimodal analysis of surface states underlying hydrogel adhesion
Akimoto AM, Tanaka N, Nihonyanagi S, Ohta Y, Enomoto T, Kuwabara N, Gao Y, Koizumi Y, Honjo K, Tahara T, Yoshida R
Res. Sq.
149) Posterior Shift of Shh–Fgf Signaling in Axolotl Limb Regeneration Drives Sequential Digit Formation
Furukawa S, Yamamoto S, Nakayama H, Ohashi A, Satoh A
iScience
148) Tendon regeneration ability in axolotl limbs
Amada R, Yamamoto S, Ohashi A, Nakayama H, Furukawa S, Satoh A
Zool. Sci.
147) Shear stress induces concentration gradient distributions of membrane proteins in live cells
Yamashiro S, Nomura N, Chapin N, Sasidharan S, Elverston L, Nagao K, Knepper L, Thévenin D, Watanabe N, Honerkamp-Smith AR
146) Lysophosphatidic acid mitigates vascular permeability and allergic rhinitis in mice
Shimizu A, Hayashi Y, Hosoe N, Takara K, Lynda L, Ishida R, Kato Y, Fujieda S, Kidoya H
Allergol Int., S1323-8930(26)00041-9 (2026)
145) Tolerance to extracellular acidic pH facilitates tumor plasticity
Hasegawa M, Xu B, Maeda K, Seki M, Cai F, Cui R, Ando R, Nakagawa S, Sakamoto A, Boycott C, Yatabe H, Nishida M, Matsumoto K, Iwabuchi-Yoshida C, Aki S, Yamagata K, Tsuchida R, Takahashi M, Kuribayashi F, Kidoya H, Hirata H, Matsumoto S, Sando S, Yanai H, Yachie N, Osawa T
144) Injectable Thixotropic Hydrogel Composed of Elastin-Like Polypeptide and Oxidized Dextran for Anastomotic Support
Aoyama Y, Nakano Y, Shinozuka T, Aoki K, Suzuki K, Ohtsuki C, Kanda M, Sugawara-Narutaki A
143) Energetics-based model for a diffusiophoretic motion of a deformable droplet
Kitahata H, Koyano Y, Kobayashi Y, Nagayama M
Phys. Rev. E, 113:035408 (2026)
142) Quantifying Lysosomal Degradation of Extracellular Proteins With a Fluorescent Protein-Based Internalization Assay
Bun S, Kamikawa K, Matsuura A, Itakura E
Bio Protoc, 16(5):e5619.(2026)
141) The integration mechanism of the four positional cues—anterior, posterior, dorsal, and ventral—in axolotl limb regeneration
Yamamoto S, Furukawa S, Ohashi A, Hamada M, Satoh A
140) Down-regulation of proliferation-inhibiting factor EGR1 in brain metastatic cancer cells on a soft matrix
Omukai M, Ishihara S, Hirata E, Haga H
Cell Struct. Funct., 51(1):139-146(2026)
139) Click-crosslinked nanogels integrated into 3D stem cell spheroids enhance regenerative function for swallowing muscle repair
Okuyama H, Brown M, Munipalle M, Nejati S, Huo R, Sakata H, Mizuta R, Sasaki Y, Akiyoshi K, Ohnishi H, Kishimoto Y, Omori K, Li Ji, Mongeau L, Li-Jessen NYK
138) Antitumor Effects of PD-1 Blockade Combined with Mild Hyperthermia in a Murine Osteosarcoma Model
Izubuchi Y, Hosoe N, Tanaka T, Watanabe Y, Kobayashi T, Nakajima H, Kidoya H, Matsumine A
Biomedicines, 14(2):341 (2026)
137) Planar cell polarity emerges through polarized accumulation of Wnt11
Mii Y, Suzuki M, Koyama H, Nakayama K, Takada R, Kobayashi T, Tsutsumi M, Nemoto T, Matsuyama M, Fujimori T, Takada S
Sci. Adv., 12, eaea0326 (2026)
136) FGF2 Rescues Denervation-Induced Muscle Atrophy in Ambystoma mexicanum
Nakayama H, Ohashi A, Yamamoto S, Furukawa S, Satoh A
135) Glomerular basement membrane structural integrity dictates trans-tissue deposition of laminin in the kidney
Omachi K, Lin MH, Puapatanakul P, Begin JF, McKee KK, Fujiwara H, Yurchenco PD, Miner JH
Cell Rep., 45(3):117006 (2026)
134) Fibroblast-specific palladin drives kidney fibrosis via MRTF-SRF signaling
Yamamoto N, Sakai N, Yamamura Y, Kaikoi D, Hayashi D, Matsuno T, Koshino A, Sako K, Horikoshi K, Yuasa T, Tamai A, Minami T, Oshima M, Nakagawa S, Kitajima S, Hara A, Shimizu M, Terakawa J, Horike SI, Daikoku T, Mizokami A, Ikeda H, Kadoguchi M, Arakawa H, Ohtsuki S, Lagares D, Wada T, Iwata Y
J. Pathol., 268(1):40-53 (2026)
133) Zinc-MTF1-metallothionein axis plays critical roles in the defense against ferroptosis in human cells
Wagatsuma T, Yamamoto A, Nishimura Y, Kawami M, Ito J, Hirayama T, Masuda S, Nakagawa K, Uchida Y, Kambe T
Free Radic. Biol. Med., 245:390-404 (2026)
132) scSurv: a deep generative model for single-cell survival analysis
Mizukoshi C, Kojima Y, Hayashi S, Abe K, Kasugai D, Shimamura T
Bioinformatics, 42(1):btaf671 (2026)
131) Reprogramming of Alveolar Macrophages by the Bacterial Peptide iEDAP via PEPT2 Transport
Kawami M, Takeuchi Y, Fuji K, Yumoto R, Takano M, Uchida Y
130) Peristaltic contractions drive gut anisotropic growth through collective cell rearrangements
Kawamura K, Takahashi Y, Inaba M
129) Non-migratory mode of ventral body wall closure: Primary mid-ventral covering is replaced by prospective definitive body wall
Buma K, Takahashi Y
128) Endothelial IRE1 signaling maintains blood-brain barrier integrity and limits neuroinflammation after traumatic brain injury
Fan Q, Takarada-Iemata M, Tanaka T, Nguyen LD, Okitani N, Yang R, Tamatani T, Ishii H, Hattori T, Kidoya H, Kubota Y, Iwawaki T, Hori O
Cell Death Dis, 17(1):210 (2026)
127) P-LM421E8, the heparan sulfate chain-conjugated laminin-421-E8 fragment, drives differentiation of human induced pluripotent stem cells into hematopoietic progenitor cells comparable to basic fibroblast growth factor in a chemically defined system
Ninomiya N, Sasaki K, Katori R, Shimizu Y, Fujita K, Taniguchi Y, Kunieda T, Tamura K, Yamada M, Sekiguchi K, Kimura H
Matrix Biol. Plus, 29 (2026) 100188
126) Designing Cross-Linked Nanogel Microfibers for the Fabrication of Hybrid Cell Spheroids with Potential Biomedical Applications
Sakata H, Hayashi S, Kinoshita N, Harada H, Mizuta R, Sawada SI, Akiyoshi K, Sasaki Y
ACS Biomater. Sci. Eng., 12(1): 489-497 (2025)
125) Anti-aligning Self-propelled Model of Two Species: Emergence of Self-organized Heterogeneous Aligned and Clustered Order
Oki T, Hatakeyama TS, Nishikawa S, Ishihara S, Namba T
J. Phys. Soc. Jpn., 95, 013001 (2026)
124) SRRM4 Knockout Helps the Human Mesenchymal Stem Cell Line to Penetrate Decellularized Cancellous Bone
Onishi I, Muraoka K, Koyanagi A, Kimura T, Kishida A, Kitagawa M, Kurata M
Bioengineering, 12: 1299 (2025)
123) CRPPA exon 6-9 deletion as a founder mutation in Chinese patients with dystroglycanopathy
Luo J, Liu Y, Song D, Yang S, Fu X, Ge L, Wei C, Cui L, Fan Y, Luo H, He Y, Xu J, Shen Q, Guo Y, Kanagawa M, Toda T, Wang J, Zhang H, Xiong H
Pediatr. Investig., 10(1):25-37 (2025)
122) Laminin-511-functionalized fibrin gel enables in-gel proliferation of human induced pluripotent stem cells
Taniguchi Y, Takizawa M, Hada A, Ishimaru A, Sekiguchi K
Matrix Biol., 142:21-32 (2025)
121) Mapping intracellular dynamics across the whole cell with spatial statistics
Okabe Y, Saito T, Nakashima O, Matsunaga D, Deguchi S
Biophys. J., 124(23):42054214 (2025)
120) Decellularized porcine pericardium supports periodontal ligament tissue regeneration and attenuates root resorption in a tooth replantation model
Hsiao M, Kimura T, Suzuki M, Hashimoto Y, Yamada M, Kim Y, Harazono Y, Yoshitake H, Terauchi M, Kishida A, Yoda T
Dent Mater J, 45(1): 72-82 (2026)
119) Ataxin-2 as a candidate blood biomarker for estimating disease status in cases of suspected glioblastoma recurrence
Garaeva F, Nakajima R, Tamai S, Tateishi K, Mukasa A, Kawabata S, Nagashima H, Natsumeda M, Hirai N, Tanaka S, Ohba S, Higa N, Arakawa Y, Kondo A, Kohzuki H, Koizumi S, Fujioka Y, Abe T, Sabit H, Kinoshita M, Uchida Y, Ohtsuki S, Nakada M
Brain Tumor Pathol., 43:43-55 (2026)
118) RNA velocity and beyond: Current advances in modeling single-cell transcriptional dynamics
Shimamura T
Allergol Int., 74(4):525-533 (2025)
117) Protocol to culture cells on genipin-mixed collagen gels with different stiffnesses
Ishihara S, Haga H
STAR Protoc, 6(4):104125.(2025)
116) Adaptive flexibility of cells through nonequilibrium entropy production
Ueda Y, Deguchi S
115) Shear-induced irreversible gelation of silica nanoparticle dispersions containing amphiphilic block copolymer
Niwa S, Katayama S, Nakamura J, Ohtsuki C, Sugawara-Narutaki A
MRS Commun., 15:1137-1143 (2025)
114) Exploring basement membrane dynamics through cross-scale imaging, manipulation, and molecular mapping
Omachi K, Fujiwara H
Matrix Biol., 141:67-81 (2025)
113) A novel method to fabricate elastin/collagen fiber composites: Proof of concept
Shinokawa K, Sugawara-Narutaki A, Kim J, Matsumoto T, Maeda E
MATER LETT-X, 26: 100255 (2025)
112) Nephronectin Mediates the Interaction between Hair Follicle Epithelial Progenitors and Dermal Stem Cells and Is Involved in Hair Cycle Progression
Liu W, Sanzen N, Abe T, Kiyonari H, Barker N, Hu Z, Fujiwara H
J Invest Dermatol, 146(3):815-819 (2026)
111) ECM-Preserving Decellularization of Dermis via Subtle Cell Membrane Disruption Induced by Subcritical Dimethyl Ether
Nakamura N, Tanabe K, Fukuhara H, Otsuki K, Shimotomai M, Shiba S, Kimura T, Kishida A
ACS Omega, 10(34): 39002-39011 (2025)
110) Differential spreading behaviors of Nodal signalling molecules in the extracellular space cooperatively shape left-right asymmetry
Ikeda T, Kawanishi T, Mii Y, Yabe T, Pelliccia J, Burdine RD, Takeda H
109) Structural characterization of newt tendon regeneration after complete transection: In vivo two-photon imaging and transmission electron microscopy
Kamiya T, Ito Y, Iwasaki T, Suzuki D, Hayashi T, Kim J, Matsumoto T, Maeda E
J. Anat., 248(3):383-394 (2025)
108) Comparative Proteomic Analysis of Endocytic Cell-Surface Proteins in Vascular and Lymphatic Endothelial Cells
Ito S, Ohishi M, Yamahiro M, Masuda T, Ohtsuki S
Biol. Pharm. Bull., 48(8):12224-1232 (2025)
107) Single-cell transcriptomic reconstruction of the human hair cycle: Capturing the temporal dynamics of skin tissue remodeling
Yokota J, Gomi T, Harada Y, Yo K, Ahn K, Sanzen N, Machida H, Shirai Y, Fujiwara H
Cell Rep., 23;44(9):116196 (2025)
106) Biological role and clinicopathological significance of leucine-rich α-2 glycoprotein 1 in the glioblastoma microenvironment
Furuta T, Miyoshi H, Moritsubo M, Nakajima R, Negoto T, Nakamura H, Morioka M, Uchida Y, Ohtsuki S, Nakada M
J Neuropathol Exp Neurol, 84(8):707-714 (2025)
105) Evaluation of the False Discovery Rate in Library-Free Search by DIA-NN Using In Vitro Human Proteome
Gu K, Kenko M, Ogawa K, Goshima N, Masuda T, Ito S, Ohtsuki S
J. Proteome Res., 24(8):3874-3883 (2025)
104) Effects of SLC6A8 mutation-induced creatine deficiency on cellular function in fibroblasts
Ito S, Uemura T, Miyano A, Shimbo H, Masuda T, Goto T, Osaka H, Wada T, Ohtsuki S
103) Functional assessment of immortalized human brain microvascular endothelial cells with different passage numbers: A case study for a prospective proposal on variability management of in vitro blood-brain barrier models
Ohki S, Fukuda M, Baba T, Wakayama N, Morio H, Ito S, Ohtsuki S, Yamaura Y, Komori T, Furihata T
102) Active matter under cyclic stretch: Modeling microtubule alignment and bundling
Tagaki T, Nishikawa S, Ishihara S
Phys. Rev. E, 112:034405 (2025)
101) Wnt-dependent mechanism of the apical constriction of roof plate cells in developing mouse spinal cord
Shinozuka T, Okubo T, Sasai N, Takada S
Front. Cell Dev. Biol., 13:1571770 (2025)
