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Development of Extracellular Environment Control Technology for Creation of Organoids Closer to Living Body


研究代表者 Research Leader 

永樂 元次 (京都大学 医生物学研究所, 教授)

Mototsugu Eiraku (Professor, Institute for Life and Medical Sciences (LiMe), Kyoto University)

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研究分担者 Research Member 

高橋 淑子 (京都大学大学院 理学研究科, 教授) 

Yoshiko Takahashi (Professor, Graduate School of Science, Kyoto University)




We have previously reported the means for cerebral, retinal, and limb bud organoids from pluripotent stem cells (ES/iPS cells). Organoid technology enables the recapitulation of organogenetic processes in vitro. However, the application of organoid technology is still limited to a few organs. The ECM is known to undergo dynamic mechanical and chemical changes during organogenesis, and designing an artificial ECM that can control these properties of the ECM in a spatiotemporal manner would allow reproducible induction of more biologically complex tissues than is possible with existing organoid technology.

In this study, we will collaborate with other research groups to visualize ECM dynamics during organoid formation. In addition, by designing artificial ECMs that can control cell adhesion, extracellular mechanical properties, biodegradability, and material permeability, we will develop new and unprecedented organoid technologies. In particular, we will focus on the induction of early embryo-like structures, brain organoids with cranial tissue, and intestinal muscle organoids that oscillate synchronously.

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