The structure of blood vessels consists of tube formed by vascular endothelial cells and extracellular matrix covering them. The basement membrane that covers blood vessel is assumed to act as a scaffold to maintain luminal structure and control extravasation. However, recent studies have shown that the ECM sleeve that covers blood vessels act on vascular formation and intercellular interactions in the tissue microenvironment. We hypothesize that the ECM sleeve acts as a "memory device" that mediates cell-to-cell communication in the tissue microenvironment, and proceed with verification using tumor tissue as a model. It has been reported that inhibition of angiogenesis induces the appearance of ECM sleeves in tumor tissues, and is involved in therapeutic resistance. In this study, we will analyze the effects of luminal basement membrane dynamics on gene expression in various cell in the microenvironment. Furthermore, the involvement of the ECM sleeve in the progression of various diseases, will be clarified by manipulating the ECM sleeve. The results of this study will elucidate the unexplored role of the ECM as a "memory device".