Our body maintains homeostasis by adapting (remodeling) cells and tissues in response to damage and stress. During this remodeling process, the molecular composition and properties of both the extracellular matrix (ECM) and cells are thought to dynamically change, but the actual conditions and functions of these changes are largely unknown. Our group will focus on the turnover of ECM dynamics, including its secretion, interaction and degradation, as well as its mechanism of interaction with cells during vascular remodeling. This project aims to clarify the function of ECM during pathogenesis, and elucidate the unknown regulatory mechanism of ECM-driven vascular remodeling by integrating two original technologies : 4D measurement technologies (morphological information, omics data, visualization and quantification) developed by Dr. Yamashiro (PI), and biomechanics for measuring mechanical stress responses developed by Dr. Deguchi (Co-PI).